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Single molecule analysis of RNA polymerase elongation reveals uniform kinetic behavior
By using single-molecule measurements, we demonstrate that the elongation kinetics of individual Escherichia coli RNA polymerase molecules are remarkably homogeneous. We find no evidence of distinct elongation states among RNA polymerases. Instead, the observed heterogeneity in transcription rates r...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The National Academy of Sciences
2002
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC129709/ https://ncbi.nlm.nih.gov/pubmed/12370445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.212358999 |
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