Single molecule analysis of RNA polymerase elongation reveals uniform kinetic behavior

By using single-molecule measurements, we demonstrate that the elongation kinetics of individual Escherichia coli RNA polymerase molecules are remarkably homogeneous. We find no evidence of distinct elongation states among RNA polymerases. Instead, the observed heterogeneity in transcription rates r...

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Autores principales: Adelman, Karen, La Porta, Arthur, Santangelo, Thomas J., Lis, John T., Roberts, Jeffrey W., Wang, Michelle D.
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 2002
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC129709/
https://ncbi.nlm.nih.gov/pubmed/12370445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.212358999
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