Single molecule analysis of RNA polymerase elongation reveals uniform kinetic behavior

By using single-molecule measurements, we demonstrate that the elongation kinetics of individual Escherichia coli RNA polymerase molecules are remarkably homogeneous. We find no evidence of distinct elongation states among RNA polymerases. Instead, the observed heterogeneity in transcription rates r...

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Main Authors: Adelman, Karen, La Porta, Arthur, Santangelo, Thomas J., Lis, John T., Roberts, Jeffrey W., Wang, Michelle D.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2002
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC129709/
https://ncbi.nlm.nih.gov/pubmed/12370445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.212358999
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