Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

The product of the von Hippel–Lindau gene, pVHL, targets the α subunits of the heterodimeric transcription factor hypoxia-inducible factor (HIF) for polyubiquitination in the presence of oxygen. The binding of pVHL to HIF is governed by the enzymatic hydroxylation of conserved prolyl residues within...

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Main Authors: Ivan, Mircea, Haberberger, Thomas, Gervasi, David C., Michelson, Kristen S., Günzler, Volkmar, Kondo, Keiichi, Yang, Haifeng, Sorokina, Irina, Conaway, Ronald C., Conaway, Joan W., Kaelin, William G.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC129695/
https://ncbi.nlm.nih.gov/pubmed/12351678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.192342099
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