Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation

Sepsis, a potentially fatal clinical syndrome, is mediated by an early (e.g., tumor necrosis factor and IL-1) and late [e.g., high mobility group B-1 (HMGB1)] proinflammatory cytokine response to infection. Specifically targeting early mediators has not been effective clinically, in part because pea...

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Главные авторы: Ulloa, Luis, Ochani, Mahendar, Yang, Huan, Tanovic, Mahira, Halperin, Daniel, Yang, Runkuan, Czura, Christopher J., Fink, Mitchell P., Tracey, Kevin J.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2002
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC129448/
https://ncbi.nlm.nih.gov/pubmed/12209006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.192222999
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