8-Oxoguanine rearranges the active site of human topoisomerase I

7,8-Dihydro-8-oxoguanine (8-oxoG) is the most common form of oxidative DNA damage in human cells. Biochemical studies have shown that 8-oxoG decreases the DNA cleavage activity of human topoisomerase I, an enzyme vital to DNA metabolism and stability. We present the 3.1-Å crystal structure of human...

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Hauptverfasser: Lesher, Diem-Thu Thieu, Pommier, Yves, Stewart, Lance, Redinbo, Matthew R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2002
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC129405/
https://ncbi.nlm.nih.gov/pubmed/12209008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.192282699
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