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Sequence selectivity of the cleavage sites induced by topoisomerase I inhibitors: a molecular dynamics study
Topoisomerase IB (Top1) inhibitors, such as camptothecin (CPT), stabilize the Top1-DNA cleavage complex in a DNA sequence-dependent manner. The sequence selectivity of Top1 inhibitors is important for targeting specific genomic sequences of therapeutic value. However, the molecular mechanisms underl...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3905861/ https://ncbi.nlm.nih.gov/pubmed/24021629 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt791 |
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