Human mitochondrial topoisomerase I

Tension generated in the circular mitochondrial genome during replication and transcription points to the need for mtDNA topoisomerase activity. Here we report a 601-aa polypeptide highly homologous to nuclear topoisomerase I. The N-terminal domain of this novel topoisomerase contains a mitochondria...

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Bibliographic Details
Main Authors: Zhang, Hongliang, Barceló, Juana M., Lee, Benson, Kohlhagen, Glenda, Zimonjic, Drazen B., Popescu, Nicholas C., Pommier, Yves
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2001
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC58513/
https://ncbi.nlm.nih.gov/pubmed/11526219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.191321998
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