Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER

Eitemau Tebyg

• Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols
  gan: Yabe, Daisuke, et al.
  Cyhoeddwyd: (2002)
• Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins
  gan: Yabe, Daisuke, et al.
  Cyhoeddwyd: (2002)
• Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner
  gan: Shao (邵威), Wei, et al.
  Cyhoeddwyd: (2016)
• Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins
  gan: Sun, Li-Ping, et al.
  Cyhoeddwyd: (2007)
• Sterol Regulatory Element-binding Protein (SREBP) Cleavage Regulates Golgi-to-Endoplasmic Reticulum Recycling of SREBP Cleavage-activating Protein (SCAP)
  gan: Shao, Wei, et al.
  Cyhoeddwyd: (2014)