Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER

Sterols inhibit their own synthesis in mammalian cells by blocking the vesicular endoplasmic reticulum-to-Golgi transport of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP), a sterol-sensing protein that escorts SREBPs. Unable to reach the Golgi, SREBPs are not p...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Espenshade, Peter J., Li, Wei-Ping, Yabe, Daisuke
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2002
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC129331/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12193656/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.182412799
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