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Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER

Sterols inhibit their own synthesis in mammalian cells by blocking the vesicular endoplasmic reticulum-to-Golgi transport of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP), a sterol-sensing protein that escorts SREBPs. Unable to reach the Golgi, SREBPs are not p...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Espenshade, Peter J., Li, Wei-Ping, Yabe, Daisuke
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC129331/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12193656/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.182412799
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