Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER
Sterols inhibit their own synthesis in mammalian cells by blocking the vesicular endoplasmic reticulum-to-Golgi transport of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP), a sterol-sensing protein that escorts SREBPs. Unable to reach the Golgi, SREBPs are not p...
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| Gepubliceerd in: | Proc Natl Acad Sci U S A |
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| Hoofdauteurs: | , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2002
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC129331/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12193656/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.182412799 |
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