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Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER
Sterols inhibit their own synthesis in mammalian cells by blocking the vesicular endoplasmic reticulum-to-Golgi transport of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP), a sterol-sensing protein that escorts SREBPs. Unable to reach the Golgi, SREBPs are not p...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The National Academy of Sciences
2002
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC129331/ https://ncbi.nlm.nih.gov/pubmed/12193656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.182412799 |
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