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Hierarchical, clustered protein interactions with U4/U6 snRNA: a biochemical role for U4/U6 proteins

During activation of the spliceosome, the U4/U6 snRNA duplex is dissociated, releasing U6 for subsequent base pairing with U2 snRNA. Proteins that directly bind the U4/U6 interaction domain potentially could mediate these structural changes. We thus investigated binding of the human U4/U6-specific p...

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Autors principals: Nottrott, Stephanie, Urlaub, Henning, Lührmann, Reinhard
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2002
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC129076/
https://ncbi.nlm.nih.gov/pubmed/12374753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf544
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