Identification of an RNA-dependent ATPase activity in mammalian U5 snRNPs.

Nuclear pre-mRNA splicing requires ATP at several steps from spliceosome assembly to product release. Here, we demonstrate that an integral component of the 20S U5 snRNP is an RNA-dependent ATPase. The ATPase activity of 20S U5 and 25S [U4/U6.U5] snRNPs purified by glycerol gradient centrifugation i...

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Bibliographic Details
Main Authors: Laggerbauer, B, Lauber, J, Lührmann, R
Format: Artigo
Language:Inglês
Published: 1996
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC145735/
https://ncbi.nlm.nih.gov/pubmed/8600454
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