Identification of an RNA-dependent ATPase activity in mammalian U5 snRNPs.
Nuclear pre-mRNA splicing requires ATP at several steps from spliceosome assembly to product release. Here, we demonstrate that an integral component of the 20S U5 snRNP is an RNA-dependent ATPase. The ATPase activity of 20S U5 and 25S [U4/U6.U5] snRNPs purified by glycerol gradient centrifugation i...
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| Veröffentlicht in: | Nucleic Acids Res |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
1996
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| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145735/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8600454/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.5.868 |
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