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Synergistic inhibition of human melanoma proliferation by combination treatment with B-Raf inhibitor BAY43-9006 and mTOR inhibitor Rapamycin

BACKGROUND: Targeted inhibition of protein kinases is now acknowledged as an effective approach for cancer therapy. However, targeted therapies probably have limited success because cancer cells have alternate pathways for survival and proliferation thereby avoiding inhibition. We tested the hypothe...

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Bibliografiske detaljer
Main Authors: Molhoek, Kerrington R, Brautigan, David L, Slingluff, Craig L
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1289294/
https://ncbi.nlm.nih.gov/pubmed/16255777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-3-39
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