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Synergistic inhibition of human melanoma proliferation by combination treatment with B-Raf inhibitor BAY43-9006 and mTOR inhibitor Rapamycin

BACKGROUND: Targeted inhibition of protein kinases is now acknowledged as an effective approach for cancer therapy. However, targeted therapies probably have limited success because cancer cells have alternate pathways for survival and proliferation thereby avoiding inhibition. We tested the hypothe...

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Detalhes bibliográficos
Main Authors: Molhoek, Kerrington R, Brautigan, David L, Slingluff, Craig L
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1289294/
https://ncbi.nlm.nih.gov/pubmed/16255777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-3-39
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