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Synergistic inhibition of human melanoma proliferation by combination treatment with B-Raf inhibitor BAY43-9006 and mTOR inhibitor Rapamycin

BACKGROUND: Targeted inhibition of protein kinases is now acknowledged as an effective approach for cancer therapy. However, targeted therapies probably have limited success because cancer cells have alternate pathways for survival and proliferation thereby avoiding inhibition. We tested the hypothe...

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Hlavní autoři: Molhoek, Kerrington R, Brautigan, David L, Slingluff, Craig L
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2005
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1289294/
https://ncbi.nlm.nih.gov/pubmed/16255777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-3-39
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