Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells

In this study, we investigated whether elimination of CD4(+)/CD25(+) Tregs using the recombinant IL-2 diphtheria toxin conjugate DAB(389)IL-2 (also known as denileukin diftitox and ONTAK) is capable of enhancing the immunostimulatory efficacy of tumor RNA-transfected DC vaccines. We show that DAB(38...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Dannull, Jens, Su, Zhen, Rizzieri, David, Yang, Benjamin K., Coleman, Doris, Yancey, Donna, Zhang, Aijing, Dahm, Philipp, Chao, Nelson, Gilboa, Eli, Vieweg, Johannes
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2005
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1288834/
https://ncbi.nlm.nih.gov/pubmed/16308572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25947
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