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Bortezomib treatment and regulatory T-cell depletion enhance the antitumor effects of adoptively infused NK cells
Ligation of inhibitory receptors renders natural killer (NK) cells inactive against autologous tumors. Recently, the proteasome inhibitor bortezomib was shown to sensitize tumors to autologous NK-cell cytotoxicity in vitro. Here, we show bortezomib augments the antitumor effects of syngeneic NK-cell...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society of Hematology
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2699233/ https://ncbi.nlm.nih.gov/pubmed/19202127 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-11-190421 |
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