CD27-Mediated Regulatory T Cell Depletion and Effector T Cell Costimulation Both Contribute to Antitumor Efficacy

CD27, a member of the TNFR superfamily, is constitutively expressed in most T cells and plays crucial roles in T cell effector functions. The costimulation and antitumor activity of CD27 agonistic Abs have been well documented in mouse models. Clinical testing of a human IgG1 anti-CD27 Ab, varliluma...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Immunol
Auteurs principaux: Wasiuk, Anna, Testa, James, Weidlick, Jeff, Sisson, Crystal, Vitale, Laura, Widger, Jenifer, Crocker, Andrea, Thomas, Lawrence J., Goldstein, Joel, Marsh, Henry C., Keler, Tibor, He, Li-Zhen
Format: Artigo
Langue:Inglês
Publié: AAI 2017
Sujets:
Immunotherapy and Vaccines
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5713498/
https://ncbi.nlm.nih.gov/pubmed/29109120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700606
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