Characterization of the human T cell response to in vitro CD27 costimulation with varlilumab

BACKGROUND: Clinical targeting of TNFR family of receptors (CD40, CD134 and CD137) with immunostimulatory monoclonal antibodies has been successful in cancer immunotherapy. However, targeting of CD27 with a mAb is a relatively new approach to provide costimulation of immune cells undergoing activati...

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Bibliografiske detaljer
Udgivet i:J Immunother Cancer
Main Authors: Ramakrishna, Venky, Sundarapandiyan, Karuna, Zhao, Biwei, Bylesjo, Max, Marsh, Henry C., Keler, Tibor
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4619281/
https://ncbi.nlm.nih.gov/pubmed/26500773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-015-0080-2
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