Safety and activity of varlilumab, a novel and first-in-class agonist anti-CD27 antibody, for hematologic malignancies

CD27, a costimulatory molecule on T cells, induces intracellular signals mediating cellular activation, proliferation, effector function, and cell survival on binding to its ligand, CD70. Varlilumab, a novel, first-in-class, agonist immunoglobulin G1 anti-CD27 antibody, mediates antitumor immunity a...

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Detalles Bibliográficos
Publicado en:Blood Adv
Main Authors: Ansell, Stephen M., Flinn, Ian, Taylor, Matthew H., Sikic, Branimir I., Brody, Joshua, Nemunaitis, John, Feldman, Andrew, Hawthorne, Thomas R., Rawls, Tracey, Keler, Tibor, Yellin, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2020
Assuntos:
Immunobiology and Immunotherapy
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7218437/
https://ncbi.nlm.nih.gov/pubmed/32380537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019001079
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