Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer β-amyloid peptide in rodent

Like acetylcholinesterase, butyrylcholinesterase (BChE) inactivates the neurotransmitter acetylcholine (ACh) and is hence a viable therapeutic target in Alzheimer's disease, which is characterized by a cholinergic deficit. Potent, reversible, and brain-targeted BChE inhibitors (cymserine analog...

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Hlavní autoři: Greig, Nigel H., Utsuki, Tadanobu, Ingram, Donald K., Wang, Yue, Pepeu, Giancarlo, Scali, Carla, Yu, Qian-Sheng, Mamczarz, Jacek, Holloway, Harold W., Giordano, Tony, Chen, DeMao, Furukawa, Katsutoshi, Sambamurti, Kumar, Brossi, Arnold, Lahiri, Debomoy K.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2005
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1288010/
https://ncbi.nlm.nih.gov/pubmed/16275899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508575102
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