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Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine

The N-monophenylcarbamate analogues of neostigmine methyl sulfate (6) and pyridostigmine bromide (8) together with their precursors (5), (7), and the N(1)-methylammonium analogues of (−)-phenserine (12), (−)-tolserine (14), (−)-cymserine (16) and (−)-phenethylcymserine (18) were synthesized to produ...

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Detalhes bibliográficos
Main Authors: Yu, Qian-sheng, Holloway, Harold W., Luo, Weiming, Lahiri, Debomoy K., Brossi, Arnold, Greig, Nigel H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989343/
https://ncbi.nlm.nih.gov/pubmed/20627738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.05.022
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