The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation

Recurrent genetic alterations in human medulloblastoma (MB) include mutations in the sonic hedgehog (SHH) signaling pathway and TP53 inactivation (∼25% and 10% of cases, respectively). However, mouse models of MB, regardless of their initiating lesions, generally depend upon p53 inactivation for rap...

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Bibliografiske detaljer
Main Authors: Uziel, Tamar, Zindy, Frederique, Xie, Suqing, Lee, Youngsoo, Forget, Antoine, Magdaleno, Susan, Rehg, Jerold E., Calabrese, Christopher, Solecki, David, Eberhart, Charles G., Sherr, Sarah E., Plimmer, Sarah, Clifford, Steven C., Hatten, Mary E., McKinnon, Peter J., Gilbertson, Richard J., Curran, Tom, Sherr, Charles J., Roussel, Martine F.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2005
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1283959/
https://ncbi.nlm.nih.gov/pubmed/16260494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1368605
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