N-Myc and the cyclin-dependent kinase inhibitors p18(Ink4c) and p27(Kip1) coordinately regulate cerebellar development

Conditional N-Myc deletion limits the proliferation of granule neuron progenitors (GNPs), perturbs foliation, and leads to reduced cerebellar mass. We show that c-Myc mRNA levels increase in N-Myc-null GNPs and that simultaneous deletion of both c- and N-Myc exacerbates defective cerebellar developm...

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Bibliografiske detaljer
Main Authors: Zindy, Frederique, Knoepfler, Paul S., Xie, Suqing, Sherr, Charles J., Eisenman, Robert N., Roussel, Martine F.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2006
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1518798/
https://ncbi.nlm.nih.gov/pubmed/16864777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604727103
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