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INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins
INSIGs are proteins that underlie sterol regulation of the mammalian proteins SCAP (SREBP cleavage activating protein) and HMG-CoA reductase (HMGR). The INSIGs perform distinct tasks in the regulation of these effectors: they promote ER retention of SCAP, but ubiquitin-mediated degradation of HMGR....
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2005
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1283954/ https://ncbi.nlm.nih.gov/pubmed/16270032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600855 |
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