Insulin-induced Gene Protein (INSIG)-dependent Sterol Regulation of Hmg2 Endoplasmic Reticulum-associated Degradation (ERAD) in Yeast

Insulin-induced gene proteins (INSIGs) function in control of cellular cholesterol. Mammalian INSIGs exert control by directly interacting with proteins containing sterol-sensing domains (SSDs) when sterol levels are elevated. Mammalian 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase (HMGR) undergoes...

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Bibliographic Details
Main Authors: Theesfeld, Chandra L., Hampton, Randolph Y.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Protein Synthesis and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605666/
https://ncbi.nlm.nih.gov/pubmed/23306196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.404517
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