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Degradation of Sterol Regulatory Element-binding Protein Precursor Requires the Endoplasmic Reticulum-associated Degradation Components Ubc7 and Hrd1 in Fission Yeast

Sre1, the fission yeast sterol regulatory element-binding protein (SREBP), is an endoplasmic reticulum (ER) membrane-bound transcription factor that is a principal regulator of hypoxic gene expression. Under low oxygen, Sre1 is cleaved from its inactive ER precursor form to generate an active nuclea...

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Bibliografske podrobnosti
Main Authors: Hughes, Bridget T., Nwosu, Christine C., Espenshade, Peter J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742815/
https://ncbi.nlm.nih.gov/pubmed/19520858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.002436
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