The Sterol-sensing Domain (SSD) Directly Mediates Signal-regulated Endoplasmic Reticulum-associated Degradation (ERAD) of 3-Hydroxy-3-methylglutaryl (HMG)-CoA Reductase Isozyme Hmg2

The sterol-sensing domain (SSD) is a conserved motif in membrane proteins responsible for sterol regulation. Mammalian proteins SREBP cleavage-activating protein (SCAP) and HMG-CoA reductase (HMGR) both possess SSDs required for feedback regulation of sterol-related genes and sterol synthetic rate....

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Hlavní autoři: Theesfeld, Chandra L., Pourmand, Deeba, Davis, Talib, Garza, Renee M., Hampton, Randolph Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Protein Synthesis and Degradation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143592/
https://ncbi.nlm.nih.gov/pubmed/21628456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.244798
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