INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins

INSIGs are proteins that underlie sterol regulation of the mammalian proteins SCAP (SREBP cleavage activating protein) and HMG-CoA reductase (HMGR). The INSIGs perform distinct tasks in the regulation of these effectors: they promote ER retention of SCAP, but ubiquitin-mediated degradation of HMGR....

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Hauptverfasser: Flury, Isabelle, Garza, Renee, Shearer, Alexander, Rosen, Johanna, Cronin, Stephen, Hampton, Randolph Y
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2005
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1283954/
https://ncbi.nlm.nih.gov/pubmed/16270032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600855
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