Mitochondrial Lipid Abnormality and Electron Transport Chain Impairment in Mice Lacking α-Synuclein

The presynaptic protein α-synuclein, implicated in Parkinson disease (PD), binds phospholipids and has a role in brain fatty acid (FA) metabolism. In mice lacking α-synuclein (Snca(−/−)), total brain steady-state mass of the mitochondria-specific phospholipid, cardiolipin, is reduced 22% and its acy...

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Main Authors: Ellis, Christopher E., Murphy, Eric J., Mitchell, Drake C., Golovko, Mikhail Y., Scaglia, Fernando, Barceló-Coblijn, Gwendolyn C., Nussbaum, Robert L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1280279/
https://ncbi.nlm.nih.gov/pubmed/16260631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.22.10190-10201.2005
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