Mice Lacking the Giant Protocadherin mFAT1 Exhibit Renal Slit Junction Abnormalities and a Partially Penetrant Cyclopia and Anophthalmia Phenotype

While roles in adhesion and morphogenesis have been documented for classical cadherins, the nonclassical cadherins are much less well understood. Here we have examined the functions of the giant protocadherin FAT by generating a transgenic mouse lacking mFAT1. These mice exhibit perinatal lethality,...

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Bibliographische Detailangaben
Hauptverfasser: Ciani, Lorenza, Patel, Anjla, Allen, Nicholas D., ffrench-Constant, Charles
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2003
Schlagworte:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC164754/
https://ncbi.nlm.nih.gov/pubmed/12724416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.10.3575-3582.2003
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