Mice Lacking the Giant Protocadherin mFAT1 Exhibit Renal Slit Junction Abnormalities and a Partially Penetrant Cyclopia and Anophthalmia Phenotype

While roles in adhesion and morphogenesis have been documented for classical cadherins, the nonclassical cadherins are much less well understood. Here we have examined the functions of the giant protocadherin FAT by generating a transgenic mouse lacking mFAT1. These mice exhibit perinatal lethality,...

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Detalhes bibliográficos
Main Authors: Ciani, Lorenza, Patel, Anjla, Allen, Nicholas D., ffrench-Constant, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC164754/
https://ncbi.nlm.nih.gov/pubmed/12724416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.10.3575-3582.2003
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