Neurons Expressing the Highest Levels of γ-Synuclein Are Unaffected by Targeted Inactivation of the Gene

Homologous recombination in ES cells was employed to generate mice with targeted deletion of the first three exons of the γ-synuclein gene. Complete inactivation of gene expression in null mutant mice was confirmed on the mRNA and protein levels. Null mutant mice are viable, are fertile, and do not...

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Main Authors: Ninkina, Natalia, Papachroni, Katerina, Robertson, Darren C., Schmidt, Oliver, Delaney, Liz, O'Neill, Francis, Court, Felipe, Rosenthal, Arnon, Fleetwood-Walker, Susan M., Davies, Alun M., Buchman, Vladimir L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2003
Teme:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC262405/
https://ncbi.nlm.nih.gov/pubmed/14585981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.22.8233-8245.2003
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