Protective Immunity against Mycobacterium tuberculosis Induced by Dendritic Cells Pulsed with both CD8(+)- and CD4(+)-T-Cell Epitopes from Antigen 85A

Immunization with DNA followed by modified vaccinia virus Ankara strain, both expressing the antigen 85A, induced both CD4(+)- and CD8(+)-T-cell responses in BALB/c mice. Following challenge with Mycobacterium tuberculosis, this prime-boost regimen produced protection equivalent to that conferred by...

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Detalhes bibliográficos
Main Authors: McShane, Helen, Behboudi, Shahriar, Goonetilleke, Nilu, Brookes, Roger, Hill, Adrian V. S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC127749/
https://ncbi.nlm.nih.gov/pubmed/11854254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.3.1623-1626.2002
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