Vaccination with Plasmid DNA Encoding Mycobacterial Antigen 85A Stimulates a CD4(+) and CD8(+) T-Cell Epitopic Repertoire Broader than That Stimulated by Mycobacterium tuberculosis H37Rv Infection

Vaccination of mice with plasmid DNA carrying the gene for the major secreted mycobacterial antigen 85A (Ag85A) from Mycobacterium tuberculosis is a powerful technique for generating robust specific Th1 helper T-cell responses, CD8(+)-mediated cytotoxicity, and protection against M. tuberculosis cha...

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Main Authors: Denis, Olivier, Tanghe, Audrey, Palfliet, Kamiel, Jurion, Fabienne, van den Berg, Thierry-P., Vanonckelen, Albert, Ooms, Josette, Saman, Eric, Ulmer, Jeffrey B., Content, Jean, Huygen, Kris
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 1998
主題:
Microbial Immunity and Vaccines
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC108084/
https://ncbi.nlm.nih.gov/pubmed/9529077
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