Vaccination with Plasmid DNA Encoding Mycobacterial Antigen 85A Stimulates a CD4(+) and CD8(+) T-Cell Epitopic Repertoire Broader than That Stimulated by Mycobacterium tuberculosis H37Rv Infection

Vaccination of mice with plasmid DNA carrying the gene for the major secreted mycobacterial antigen 85A (Ag85A) from Mycobacterium tuberculosis is a powerful technique for generating robust specific Th1 helper T-cell responses, CD8(+)-mediated cytotoxicity, and protection against M. tuberculosis cha...

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Главные авторы: Denis, Olivier, Tanghe, Audrey, Palfliet, Kamiel, Jurion, Fabienne, van den Berg, Thierry-P., Vanonckelen, Albert, Ooms, Josette, Saman, Eric, Ulmer, Jeffrey B., Content, Jean, Huygen, Kris
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 1998
Предметы:
Microbial Immunity and Vaccines
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC108084/
https://ncbi.nlm.nih.gov/pubmed/9529077
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