Potent and Selective Inhibition of Human Cytomegalovirus Replication by 1263W94, a Benzimidazole l-Riboside with a Unique Mode of Action

Benzimidazole nucleosides have been shown to be potent inhibitors of human cytomegalovirus (HCMV) replication in vitro. As part of the exploration of structure-activity relationships within this series, we synthesized the 2-isopropylamino derivative (3322W93) of 1H-β-d-ribofuranoside-2-bromo-5,6-dic...

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Autori principali: Biron, Karen K., Harvey, Robert J., Chamberlain, Stanley C., Good, Steven S., Smith III, Albert A., Davis, Michelle G., Talarico, Christine L., Miller, Wayne H., Ferris, Robert, Dornsife, Ronna E., Stanat, Sylvia C., Drach, John C., Townsend, Leroy B., Koszalka, George W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2002
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC127361/
https://ncbi.nlm.nih.gov/pubmed/12121906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.8.2365-2372.2002
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