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Potent and Selective Inhibition of Human Cytomegalovirus Replication by 1263W94, a Benzimidazole l-Riboside with a Unique Mode of Action

Benzimidazole nucleosides have been shown to be potent inhibitors of human cytomegalovirus (HCMV) replication in vitro. As part of the exploration of structure-activity relationships within this series, we synthesized the 2-isopropylamino derivative (3322W93) of 1H-β-d-ribofuranoside-2-bromo-5,6-dic...

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Uloženo v:
Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Biron, Karen K., Harvey, Robert J., Chamberlain, Stanley C., Good, Steven S., Smith III, Albert A., Davis, Michelle G., Talarico, Christine L., Miller, Wayne H., Ferris, Robert, Dornsife, Ronna E., Stanat, Sylvia C., Drach, John C., Townsend, Leroy B., Koszalka, George W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2002
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127361/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12121906/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.8.2365-2372.2002
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