Potent and Selective Inhibition of Human Cytomegalovirus Replication by 1263W94, a Benzimidazole l-Riboside with a Unique Mode of Action

Benzimidazole nucleosides have been shown to be potent inhibitors of human cytomegalovirus (HCMV) replication in vitro. As part of the exploration of structure-activity relationships within this series, we synthesized the 2-isopropylamino derivative (3322W93) of 1H-β-d-ribofuranoside-2-bromo-5,6-dic...

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Publicado en:	Antimicrob Agents Chemother
Autores principales:	Biron, Karen K., Harvey, Robert J., Chamberlain, Stanley C., Good, Steven S., Smith III, Albert A., Davis, Michelle G., Talarico, Christine L., Miller, Wayne H., Ferris, Robert, Dornsife, Ronna E., Stanat, Sylvia C., Drach, John C., Townsend, Leroy B., Koszalka, George W.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 2002
Materias:	Antiviral Agents
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127361/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12121906/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.8.2365-2372.2002
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