ATP-Dependent Removal of Nucleoside Reverse Transcriptase Inhibitors by Human Immunodeficiency Virus Type 1 Reverse Transcriptase

Removal of nucleoside chain terminator inhibitors mediated by human immunodeficiency virus (HIV) reverse transcriptase (RT) using ATP as an acceptor molecule has been proposed as a novel mechanism of HIV resistance. Recombinant wild-type and mutant HIV type 1 (HIV-1) RT enzymes with thymidine analog...

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Bibliographic Details
Main Authors: Naeger, Lisa K., Margot, Nicolas A., Miller, Michael D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC127313/
https://ncbi.nlm.nih.gov/pubmed/12069972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.7.2179-2184.2002
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