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Effects of the K65R and K65R/M184V reverse transcriptase mutations in subtype C HIV on enzyme function and drug resistance

<p>Abstract</p> <p>Background</p> <p>We investigated the effects of mutations K65R and K65R plus M184V on enzymatic function and mechanisms of drug resistance in subtype C reverse transcriptase (RT).</p> <p>Methods</p> <p>Recombinant subtype C HIV-1 RTs containing K65R or K65R+M184V were purified fr...

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Principais autores: Coutsinos Dimitrios, Ntemgwa Michel L, Martinez-Cajas Jorge L, Xu Hong-Tao, Frankel Fernando A, Brenner Bluma G, Wainberg Mark A
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2009-02-01
Serier:Retrovirology
Online adgang:http://www.retrovirology.com/content/6/1/14
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