Virulence and Reduced Fitness of Simian Immunodeficiency Virus with the M184V Mutation in Reverse Transcriptase

Drug-resistant mutants with a methionine-to-valine substitution at position 184 of reverse transcriptase (M184V) emerged within 5 weeks of initiation of therapy in four newborn macaques infected with simian immunodeficiency virus (SIVmac251) and treated with lamivudine (3TC) or emtricitabine [(−)-FT...

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Detalhes bibliográficos
Main Authors: Van Rompay, Koen K. A., Matthews, Tim B., Higgins, Joanne, Canfield, Don R., Tarara, Ross P., Wainberg, Mark A., Schinazi, Raymond F., Pedersen, Niels C., North, Thomas W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC136201/
https://ncbi.nlm.nih.gov/pubmed/12021341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.12.6083-6092.2002
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