Virulence and Reduced Fitness of Simian Immunodeficiency Virus with the M184V Mutation in Reverse Transcriptase

Drug-resistant mutants with a methionine-to-valine substitution at position 184 of reverse transcriptase (M184V) emerged within 5 weeks of initiation of therapy in four newborn macaques infected with simian immunodeficiency virus (SIVmac251) and treated with lamivudine (3TC) or emtricitabine [(−)-FT...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Van Rompay, Koen K. A., Matthews, Tim B., Higgins, Joanne, Canfield, Don R., Tarara, Ross P., Wainberg, Mark A., Schinazi, Raymond F., Pedersen, Niels C., North, Thomas W.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2002
Assuntos:	Vaccines and Antiviral Agents
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136201/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12021341/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.12.6083-6092.2002
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