Induction of unique structural changes in guanine-rich DNA regions by the triazoloacridone C-1305, a topoisomerase II inhibitor with antitumor activities

We recently reported that the antitumor triazoloacridone, compound C-1305, is a topoisomerase II poison with unusual properties. In this study we characterize the DNA interactions of C-1305 in vitro, in comparison with other topoisomerase II inhibitors. Our results show that C-1305 binds to DNA by i...

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Detalhes bibliográficos
Main Authors: Lemke, Krzysztof, Wojciechowski, Marcin, Laine, William, Bailly, Christian, Colson, Pierre, Baginski, Maciej, Larsen, Annette K., Skladanowski, Andrzej
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1270948/
https://ncbi.nlm.nih.gov/pubmed/16254080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki904
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