PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells()

Two cellular proteins encoded by the breast and ovarian cancer type 1 susceptibility (BRCA1 and BRCA2) tumor suppressor genes are essential for DNA integrity and the maintenance of genomic stability. Approximately 5–10% of breast and ovarian cancers result from inherited alterations or mutations in...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Węsierska-Gądek, Józefa, Zulehner, Nora, Ferk, Franziska, Składanowski, Andrzej, Komina, Oxana, Maurer, Margarita
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier Science 2012
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494830/
https://ncbi.nlm.nih.gov/pubmed/22906755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.07.024
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares