The interaction between p53 and DNA topoisomerase I is regulated differently in cells with wild-type and mutant p53

DNA topoisomerase I is a nuclear enzyme involved in transcription, recombination, and DNA damage recognition. Previous studies have shown that topoisomerase I interacts directly with the tumor-suppressor protein p53. p53 is a transcription factor that activates certain genes through binding to speci...

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Podrobná bibliografie

Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Gobert, Céline, Skladanowski, Andrzej, Larsen, Annette K.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 1999
Témata:	Biological Sciences
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17892/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10468612/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.18.10355
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