The interaction between p53 and DNA topoisomerase I is regulated differently in cells with wild-type and mutant p53
DNA topoisomerase I is a nuclear enzyme involved in transcription, recombination, and DNA damage recognition. Previous studies have shown that topoisomerase I interacts directly with the tumor-suppressor protein p53. p53 is a transcription factor that activates certain genes through binding to speci...
שמור ב:
| הוצא לאור ב: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
National Academy of Sciences
1999
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17892/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10468612/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.18.10355 |
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