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The interaction between p53 and DNA topoisomerase I is regulated differently in cells with wild-type and mutant p53

DNA topoisomerase I is a nuclear enzyme involved in transcription, recombination, and DNA damage recognition. Previous studies have shown that topoisomerase I interacts directly with the tumor-suppressor protein p53. p53 is a transcription factor that activates certain genes through binding to speci...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Gobert, Céline, Skladanowski, Andrzej, Larsen, Annette K.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17892/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10468612/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.18.10355
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