Triazoloacridone C-1305 impairs XBP1 splicing by acting as a potential IRE1α endoribonuclease inhibitor

Inositol requiring enzyme 1 alpha (IRE1α) is one of three signaling sensors in the unfolding protein response (UPR) that alleviates endoplasmic reticulum (ER) stress in cells and functions to promote cell survival. During conditions of irrevocable stress, proapoptotic gene expression is induced to p...

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Detalhes bibliográficos
Publicado no:Cell Mol Biol Lett
Main Authors: Bartoszewska, Sylwia, Króliczewski, Jarosław, Crossman, David K., Pogorzelska, Aneta, Bagiński, Maciej, Collawn, James F., Bartoszewski, Rafal
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7968329/
https://ncbi.nlm.nih.gov/pubmed/33730996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s11658-021-00255-y
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